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If you are struggling with your weight, a healthy eating plan and regular physical activity may help you lose weight and keep it off over the long term. If these lifestyle changes are not enough to help you lose weight or maintain your weight loss, your health care professional may prescribe medications as part of your weight-control program. Obesity is a chronic disease that affects more than 4 in 10 adults in the United States, and nearly 1 in 10 Americans have severe obesity.
Prescription medications to treat overweight and obesity work in different ways. For example, some medications may help you feel less hungry or full sooner.
Other medications may make it harder for your body to absorb fat from the foods you eat. Weight management medications are meant to help people who have health problems related to overweight or obesity. Health care professionals use BMI to help decide whether you might benefit from weight management medications.
Your health care professional may prescribe a medication to treat your overweight or obesity if you are an adult with. If you are overweight or have obesity, you might be able to lose weight with a lifestyle program that changes your behaviors and improves your eating and physical activity habits. A lifestyle program may also address other things that cause you to gain weight, such as eating triggers and not getting enough sleep.
Most of the weight management medications approved by the U. Two prescription medications, orlistat Xenical 2 and liraglutide Saxenda , 3 are approved by the FDA for children ages 12 and older. Studies show that weight management medications work best when combined with a lifestyle program.
Ask your health care professional about lifestyle treatment programs for weight management that will work for you. When combined with changes to behavior, including healthy eating and increased physical activity, prescription medications help some people lose weight and maintain weight loss.
Losing weight also can improve some other health problems related to overweight and obesity, such as joint pain and sleep apnea. Most weight loss takes place within the first 6 months of starting the medication. Experts are concerned that, in some cases, the side effects of prescription medications that treat overweight and obesity may outweigh the benefits. For this reason, never take a weight management medication only to improve the way you look.
In the past, some weight management medications were linked to serious health problems, and they were removed from U. Possible side effects vary by medication and how it acts on your body. Side effects: Actual effects can vary depending on the dosage prescribed, with some of the most common being dry mouth, constipation, tingling or prickling of the skin, insomnia, irritability, and changes in taste.
Some people also experience headaches, insomnia, depression, anxiety, fatigue, and blurred vision. Who may benefit: Your physician may prescribe Qsymia if you have a body mass index BMI over 30, or a BMI of 27 or higher along with a weight-related condition such as type 2 diabetes or high blood pressure.
Risks: Exposure to this drug combination during pregnancy may increase the risk of the baby being born with cleft lip or cleft palate. How it works: Saxenda liraglutide , is an injectable medication that reduces food intake by decreasing appetite and increasing feelings of fullness.
Effectiveness: A review found that, after one year, the average user lost between 8. Side effects: Gastrointestinal side effects nausea, diarrhea, constipation are the most common with Saxenda, especially when first taking the drug. Other potential effects include headaches and low blood sugar.
Who may benefit: Saxenda is designed to be used by people who have obesity with a BMI of 30 or more or by people who have a BMI of 27 or more and a weight-related medical condition such as type 2 diabetes, high cholesterol, or high blood pressure. Risks: Gallbladder disease, acute pancreatitis, and severe hypoglycemia are a few safety concerns associated with Saxenda. This drug shouldn't be taken by people who take insulin, people who are breastfeeding, or those with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2.
How it works: Contrave a combination of naltrexone hydrochloride and bupropion hydrochloride affects the central nervous system to increase the number of calories burned and reduce appetite. This pill is often prescribed along with a reduced-calorie diet and exercise program. Effectiveness: Research indicates that people taking Contrave lose more weight than those taking a placebo, with a mean loss of 5.
Side effects: The most common side effects are nausea, vomiting, diarrhea or constipation, headache, dizziness, insomnia, and dry mouth.
The buproprion in Contrave can also cause suicidal thoughts or actions, particularly when first taking it. Who may benefit: Contrave is designed for people with a BMI of 30 or higher, or those with a BMI of 27 and up with another weight-related medical condition. Risks: Contrave may increase your risk of seizures, increased blood pressure or heart rate, low blood sugar, liver damage, visual issues, and manic episodes.
How it works: Phentermine—which is marketed under a long list of names, including Suprenza, Adipex-P , and Lomaira—works by decreasing appetite. Effectiveness: A controlled trial reported that A study adds that taking this drug for three months or more can provide greater weight loss.
Side effects: Side effects can include insomnia, diarrhea or constipation, vomiting, an unpleasant taste, and dry mouth. Who may benefit: Like many of the other prescription weight-loss drugs, phentermine is designed for people with a BMI of 30 or higher, or those with a BMI of 27 who have other weight-related medical conditions.
Risks: This drug should not be used by people who are pregnant or nursing, or those with cardiovascular disease, hyperthyroidism, glaucoma, or a history of drug abuse. How it works : Wegovy , a weekly injection of semaglutide, works by reducing appetite, decreasing calorie intake. It activates areas of the brain responsible for appetite regulations and food intake. Effectiveness : Trials showed that treatment with Wegovy produced a statistically significant reduction in body weight over the course of 68 weeks.
Subjects lost Side effects : The most common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, and gastroesophageal reflux disease. It can also cause hypersensitivities such as anaphylaxis, retinopathy in diabetics, heart palpitations, or a racing heartbeat.
Suicidal ideation is also a potential side effect, as seen with other weight loss medications. Who may benefit : Wegovy may benefit adults with a starting BMI of greater than 30 obesity or greater than 27 overweight who have at least one weight-related health condition such as hypertension, type 2 diabetes mellitus, or dyslipidemia.
Risks : This drug should not be used by people who are pregnant or who are planning to become pregnant. Personal or family history of medullary thyroid carcinoma MTC or patients with m ultiple endocrine neoplasia type 2 MEN 2 should not take Wegovy.
Nor should patients who have had a previous hypersensitivity reaction to semaglutide or any of the ingredients in Wegovy. When purchasing a non-prescription weight loss aid, it's important to know that while OTC medications are FDA-approved for safety and effectiveness, weight loss supplements are not.
It's the responsibility of supplement manufacturers to ensure that these products are safe. For this reason, it is important to be careful when buying a diet supplement or popular herbal supplement for weight loss. The FDA also does not approve most of the claims that companies make about their products.
In many cases, weight loss claims are carefully crafted to make the product sound more effective than it is. How it works: The only over-the-counter weight loss pill approved by the FDA, Alli , contains a lower dose of orlistat 60 mg , the same medication that is in Xenical.
It works by reducing the body's absorption of fat. Effectiveness: One review of 33 randomized controlled trials involving 9, participants reports that orlistat provides a "slight but significant decrease in body weight. Who may benefit: This OTC weight loss drug is for adults with a BMI of 25 or above and should be combined with a low-calorie , low-fat diet.
Risks: Alli should not be used by people who are pregnant or breastfeeding, people who have had an organ transplant, those who've been diagnosed with food absorption issues, or those taking cyclosporine. Orlistat may increase the risk of kidney damage and osteoporosis, and it may also interact with some drugs, such as warfarin and antiretroviral medications. Alli was voluntarily removed from the market in after a tampering scare, but the company re-released it with a tamper-evident package in How it works: Garcinia cambogia is derived from a fruit that grows in warmer climates and is said to assist with weight loss by reducing appetite.
Effectiveness: Claims made by sellers have not been supported by scientific research. There is little evidence to support its effectiveness. A review published in reports that results are mixed—some people appear to lose weight with this substance while others do not.
Side effects: Adverse effects associated with taking garcinia cambogia can include headache, nausea, diarrhea, and other gastrointestinal issues. Who may benefit: Studies that have found garcinia cambogia effective for weight loss report that this effect is the same regardless of age, sex, or any other weight-related conditions. It may be better at reducing visceral fat belly fat than some other substances. Risks: While rare, the use of this substance may result in liver damage, and it is unclear whether it is safe for people who are pregnant or breastfeeding.
How it works: The name of this diet supplement may not sound familiar, but you've probably seen products that contain glucomannan , which is basically a fiber supplement. Lipozene is one. Effectiveness: In , authors of a review study reported that they could not confirm that this fiber substance can actually promote weight loss. Side effects: People taking glucomannan may notice that they belch more often and feel bloated, as well as having feelings of stomach fullness—at least for the first few days.
Diarrhea and constipation might also occur, particularly when taken in higher doses. Who may benefit: Some studies that connect glucomannan with weight loss show more positive findings in female subjects, with even greater effects when this supplement is combined with garcinia cambogia.
Risks: The EFSA Panel on Food Additives and Nutrient Sources states that this supplement presents no concern for being toxic or allergenic as long as dosing stays below 3 grams per day. On January 10, , the FDA announced that glucomannan would be added to the definition of dietary fiber after receiving a petition from a citizen , enabling it to be included on products' Nutrition and Supplement Facts labels. How it works: Conjugated linoleic acid CLA occurs naturally in meat, dairy, and vegetable oil and is thought to assist with weight loss, in part, by reducing the body's absorption of fat.
Effectiveness: A review of seven studies concluded that CLA might promote weight loss, but the difference in taking this substance versus taking a placebo is relatively small. Another study found that some people who took a CLA supplement experienced increased insulin resistance and lower HDL cholesterol levels.
Side effects: Potential side effects include constipation, diarrhea, soft stools, and abdominal pain. Who may benefit: CLA has been found to provide anti-inflammatory effects and improved lipid profiles. Risks: Some people have experienced a myocardial infarction heart attack after taking CLA, so this supplement might not be advised for people with heart issues.
How it works: Raspberry ketones come from red raspberries it gives them their smell. The claim is that the product can reduce weight by breaking down and reducing fat storage, and increasing metabolism. Effectiveness: This weight loss supplement became popular after Dr. Oz mentioned it on his TV show, but there is not enough evidence to support the claims that raspberry ketones can help humans lose weight.
Side effects: People taking raspberry ketones may feel jittery and have increased blood pressure and heart rate. Who may benefit: It is currently unclear whether this dietary supplement offers any real health benefits.
Plus, many products contain a much higher amount than has been determined safe mg per day. Risks: Research suggests that raspberry ketones may be associated with coronary vasospasm, which is when the coronary arteries suddenly constrict and reduce blood flow to the heart. Additional studies indicate that this supplement may interfere with the medication warfarin and be unsafe for people who are pregnant or lactating. How it works: Forskolin is an extract from the coleus forskohlii plant advertised as a diet supplement, carb blocker, and fat burner.
Effectiveness: Some studies have found that forskolin may help with weight loss, whereas others have found it doesn't, so its effectiveness is not yet proven. Side effects: Side effects can include increased bowel movements and loose stool and generally reduce over time.
Who may benefit: One small study found that people taking forskolin had increased HDL cholesterol levels the "good" cholesterol and improvements in their insulin concentration and resistance when combined with a low-calorie diet. Risks: This supplement may pose risks for people with polycystic kidney disease.
How it works: Meratrim is a mixture of extracts taken from the flower heads of the Sphaeranthus indicus plant and the fruit rind from Garcinia mangostana and is thought to help reduce weight by reducing appetite. Effectiveness: A study of 60 participants with a mean BMI of Side effects: While some study participants did experience nausea, stomach pain or discomfort, and gastritis, researchers concluded that these effects were not related to Meratrim use because the placebo group also experienced effects.
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